6-ECDCA (INT-747), FXR agonist (ab144246)
Key features and details
- Potent and selective FXR agonist
- CAS Number: 459789-99-2
- Purity: > 95%
- Soluble in ethanol to 50 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
6-ECDCA (INT-747), FXR agonist -
Description
Potent and selective FXR agonist -
Purity
> 95% -
CAS Number
459789-99-2 -
Chemical structure
Properties
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Chemical name
(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-Ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid -
Molecular weight
420.63 -
Molecular formula
C26H44O4 -
PubChem identifier
447715 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab144246 has been referenced in 1 publication.
- Gai Z et al. Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage. Sci Rep 7:9815 (2017). PubMed: 28852062