(R)-CPP (mM/ml), NMDA antagonist (ab144495)
Key features and details
- Potent NMDA antagonist. 1 ml water soluble pack.
- CAS Number: 126453-07-4
- Soluble in 1 ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R)-CPP (mM/ml), NMDA antagonist -
Description
Potent NMDA antagonist. 1 ml water soluble pack. -
Biological description
Highly potent, competitive NMDA antagonist; more active enantiomer of (RS)-CPP (ab120160). (Ki values are 0.04, 0.3, 0.6 and 2.0 μM at NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D, respectively).
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
CAS Number
126453-07-4 -
Chemical structure
Properties
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Chemical name
(R)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid -
Molecular weight
252.20 -
Molecular formula
C8H17N2O5P -
PubChem identifier
6603754 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 ml water to give specified mM/ml concentration -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)[C@H]1CN(CCCP(=O)(O)O)CCN1 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab144495 has been referenced in 6 publications.
- Apostolides PF & Trussell LO Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse. J Neurosci 33:4768-81 (2013). PubMed: 23486948
- Bock R et al. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci 16:632-8 (2013). PubMed: 23542690
- Pugh JR & Jahr CE Axonal GABAA receptors increase cerebellar granule cell excitability and synaptic activity. J Neurosci 31:565-74 (2011). PubMed: 21228165
- Chanda S & Xu-Friedman MA Excitatory modulation in the cochlear nucleus through group I metabotropic glutamate receptor activation. J Neurosci 31:7450-5 (2011). PubMed: 21593328
- Herman MA et al. Distribution of extracellular glutamate in the neuropil of hippocampus. PLoS One 6:e26501 (2011). PubMed: 22069455
- Bagnall MW et al. Glycinergic projection neurons of the cerebellum. J Neurosci 29:10104-10 (2009). PubMed: 19675244