Anti-MelanA antibody (ab15468)

Overview

• Product nameAnti-MelanA antibodySee all MelanA primary antibodies ...
• Description
  Rabbit polyclonal to MelanA
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length protein (Human).

• Positive controlMelanoma

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: 1% BSA, 10mM PBS, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Tumor immunology
  • Tumor-associated antigens

  • Tags & Cell Markers
  • Cell Type Markers
  • Tumor Associated

Applications

Target

• FunctionInvolved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
• Tissue specificityExpression is restricted to melanoma and melanocyte cell lines and retina.
• Post-translational
  modificationsAcylated.
• Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Target information above from: UniProt accession Q16655 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2315 Human
  • Omim: 605513 Human
  • SwissProt: Q16655 Human
  • Unigene: 154069 Human

• Alternative names
  Antigen LB39 AA antibodyAntigen LB39-AA antibodyAntigen SK29 AA antibody

  Antigen SK29-AA antibodyMAR1_HUMAN antibodyMART 1 antibodyMART-1 antibodyMART1 antibodyMelan A antibodyMelan A protein antibodyMelanoma antigen recognized by T cells 1 antibodyMelanoma antigen recognized by T-cells 1 antibodyMLAN A antibodyMLANA antibodyOTTHUMP00000021036 antibodyOTTHUMP00000021037 antibodyOTTHUMP00000021038 antibodyProtein Melan-A antibody

  see all

Anti-MelanA antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MelanA antibody (ab15468)
  Human melanoma stained with anti-MelanA antibody, ab15468 by Immunohistochemistry (FFPE-sections).
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MelanA antibody (ab15468)Image from Tammela T et al., Sci Transl Med, 3, 69ra11. Fig 1.; doi: 10.1126/scitranslmed.3001699.

  Immunohistochemical analysis of Human lymphatic vessels from melanoma patients, staining MelanA (white) with ab15468.