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Overview

  • Product nameNeuroD1 peptideSee all NeuroD1 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 100 - 200 of Human NeuroD1. (Note: the amino acid sequence is proprietary)
  • Protein length337 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab16508.

    • Protein info

    • Alternative names
        atonalbasic helix loop helix transcription factorBETA 2
        Beta cell E box transactivator 2BETA2BETA2BHF 1BHF1BHF1bHLHa3class A basic helix loop helix protein 3Class A basic helix-loop-helix protein 3MODY 6MODY6NDF1_HUMANNEURODNeuroD1Neurogenic differentiation 1Neurogenic differentiation factor 1Neurogenic differentiation factor 1neurogenic helix loop helix protein NEURODNIDDMNIDDM
      see all
  • FunctionDifferentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • Involvement in diseaseDefects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • Cellular localizationCytoplasm. Nucleus.

    • Target information above from: UniProt accession Q13562 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for NeuroD1 peptide (ab17100)

    ab17100 has not yet been referenced specifically in any publications.

    Publishing research using ab17100 ? Please let us know so that we can cite the reference in this datasheet

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