Anti-GHRH antibody (ab187512)
Key features and details
- Rabbit polyclonal to GHRH
- Suitable for: WB, ICC/IF, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-GHRH antibody
See all GHRH primary antibodies -
Description
Rabbit polyclonal to GHRH -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Recombinant full length protein corresponding to Human GHRH.
Database link: P01286 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab187512 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use at an assay dependent concentration.
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ICC/IF | (2) |
Use at an assay dependent concentration.
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IHC-P | (1) |
1/50 - 1/200.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
Notes |
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WB
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
1/50 - 1/200. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
Target
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Function
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. -
Sequence similarities
Belongs to the glucagon family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2691 Human
- Entrez Gene: 14601 Mouse
- Entrez Gene: 29446 Rat
- GenBank: NP_066567.1 Human
- Omim: 139190 Human
- SwissProt: P01286 Human
- SwissProt: P16043 Mouse
- SwissProt: P09916 Rat
see all -
Alternative names
- GHRF antibody
- GHRH antibody
- GRF antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab187512 has been referenced in 8 publications.
- Lamback EB et al. Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma. Arch Endocrinol Metab 65:648-663 (2021). PubMed: 34591404
- Yan W et al. MOUSE RETINAL CELL ATLAS: MOLECULAR IDENTIFICATION OF OVER SIXTY AMACRINE CELL TYPES. J Neurosci N/A:N/A (2020). PubMed: 32457074
- Popovics P et al. Growth hormone-releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis. Prostate 78:970-980 (2018). PubMed: 29786867
- Jimenez JJ et al. A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone. Br J Haematol 181:476-485 (2018). PubMed: 29663325
- Sasanuma H et al. PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis. Mol Metab 6:428-439 (2017). IHC-P ; Mouse . PubMed: 28462077
- Tang S et al. Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy. Sci Rep 7:18110 (2017). PubMed: 29273763
- Popovics P et al. Antagonists of growth hormone-releasing hormone inhibit proliferation induced by inflammation in prostatic epithelial cells. Proc Natl Acad Sci U S A 114:1359-1364 (2017). PubMed: 28123062
- Gan J et al. Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-?B signaling. Proc Natl Acad Sci U S A 113:14745-14750 (2016). PubMed: 27930339