Anti-CaV1.3 antibody - C-terminal (ab191038)
Key features and details
- Rabbit polyclonal to CaV1.3 - C-terminal
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
-
Product name
Anti-CaV1.3 antibody - C-terminal
See all CaV1.3 primary antibodies -
Description
Rabbit polyclonal to CaV1.3 - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat
Predicted to work with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human CaV1.3 aa 2100 to the C-terminus (C terminal).
Database link: Q01668 -
Positive control
- Rat brain tissue lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191038 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 245 kDa (predicted molecular weight: 245 kDa).
|
Notes |
---|
WB
Use a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 245 kDa (predicted molecular weight: 245 kDa). |
Target
-
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). -
Tissue specificity
Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. -
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. -
Domain
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 776 Human
- Entrez Gene: 12289 Mouse
- Entrez Gene: 29716 Rat
- Omim: 114206 Human
- SwissProt: Q01668 Human
- SwissProt: Q99246 Mouse
- SwissProt: P27732 Rat
- Unigene: 476358 Human
see all -
Alternative names
- alpha-1 polypeptide antibody
- CAC1D_HUMAN antibody
- CACH3 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (2)
ab191038 has been referenced in 2 publications.
- Sohn J et al. Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. Stem Cell Res Ther 9:86 (2018). WB . PubMed: 29615119
- Kanatani S et al. Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii. PLoS Pathog 13:e1006739 (2017). WB . PubMed: 29216332