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Anti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC) (ab21851)

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Overview

  • Product nameAnti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC)See all CD41/Integrin alpha 2b primary antibodies ...
  • Description
    Mouse monoclonal [MEM-06] to CD41/Integrin alpha 2b (FITC)
  • ConjugationFITC
  • Conjugation notesThe purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue / cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).

Properties

Applications

Our Abpromise guarantee covers the use of ab21851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt
  • Application notesFlow Cyt: Use 20µl of antibody per 100µl whole blood.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    • Tissue specificityIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
    • Involvement in diseaseDefects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
    • Sequence similaritiesBelongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession P08514 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          antigen CD41 antibodyBDPLT2 antibodyCD41 antibody
          cd41 antigen antibodyCD41a antibodycd41b antibodyform 2 antibodygp2b antibodyGPalpha IIb antibodygpalphaiib antibodygpiib antibodyGT antibodygta antibodyHPA3 antibodyIntegrin alpha 2b antibodyIntegrin alpha IIb antibodyIntegrin alpha-IIb light chain antibodyITA2B_HUMAN antibodyITGA2B antibodyITGAB antibodyplatelet fibrinogen receptor alpha antibodyplatelet fibrinogen receptor, alpha subunit antibodyplatelet glycoprotein IIb of IIb/IIIa complex antibodyplatelet membrane glycoprotein iib antibodyplatelet specific antigen bak antibody
        see all

      References for Anti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC) (ab21851)

      ab21851 has not yet been referenced specifically in any publications.

      Publishing research using ab21851 ? Please let us know so that we can cite the reference in this datasheet

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