Anti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC) (ab21851)
- Product nameAnti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC)See all CD41/Integrin alpha 2b primary antibodies ...
- DescriptionMouse monoclonal [MEM-06] to CD41/Integrin alpha 2b (FITC)
- Conjugation notesThe purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
- Tested applicationsFlow Cyt more details
- Species reactivityReacts with: Human
Tissue / cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).
- Storage instructionsStore at +4°C in the dark. Do not freeze.
- Storage bufferPreservative: 15mM Sodium Azide
Constituents: PBS, BSA. pH 7.4
- Concentration information loading...
- PurityProtein G purified
- Clonality Monoclonal
- Clone numberMEM-06
Our Abpromise guarantee covers the use of ab21851 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
- Tissue specificityIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
- Involvement in diseaseDefects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
- Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
- Cellular localizationMembrane.
- antigen CD41 antibodyBDPLT2 antibodyCD41 antibody
- cd41 antigen antibodyCD41a antibodycd41b antibodyform 2 antibodygp2b antibodyGPalpha IIb antibodygpalphaiib antibodygpiib antibodyGT antibodygta antibodyHPA3 antibodyIntegrin alpha 2b antibodyIntegrin alpha IIb antibodyIntegrin alpha-IIb light chain antibodyITA2B_HUMAN antibodyITGA2B antibodyITGAB antibodyplatelet fibrinogen receptor alpha antibodyplatelet fibrinogen receptor, alpha subunit antibodyplatelet glycoprotein IIb of IIb/IIIa complex antibodyplatelet membrane glycoprotein iib antibodyplatelet specific antigen bak antibody
References for Anti-CD41/Integrin alpha 2b antibody [MEM-06] (FITC) (ab21851)
ab21851 has not yet been referenced specifically in any publications.