Anti-HGF antibody (ab24865)
Key features and details
- Rabbit polyclonal to HGF
- Suitable for: WB, Sandwich ELISA
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-HGF antibody
See all HGF primary antibodies -
Description
Rabbit polyclonal to HGF -
Host species
Rabbit -
Tested applications
Suitable for: WB, Sandwich ELISAmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length HGF (Human)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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sELISA pair antibody
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab24865 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa.
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Sandwich ELISA |
Use a concentration of 0.5 µg/ml. Can be paired for Sandwich ELISA with Mouse monoclonal [EGH2 4C12.1] to HGF (ab10829).
For sandwich ELISA, use this antibody as Detection at 0.5µg/ml with ab10829 as Capture. |
Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa. |
Sandwich ELISA
Use a concentration of 0.5 µg/ml. Can be paired for Sandwich ELISA with Mouse monoclonal [EGH2 4C12.1] to HGF (ab10829). For sandwich ELISA, use this antibody as Detection at 0.5µg/ml with ab10829 as Capture. |
Target
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Function
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. -
Involvement in disease
Deafness, autosomal recessive, 39 -
Sequence similarities
Belongs to the peptidase S1 family. Plasminogen subfamily.
Contains 4 kringle domains.
Contains 1 PAN domain.
Contains 1 peptidase S1 domain. - Information by UniProt
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Database links
- Entrez Gene: 3082 Human
- Omim: 142409 Human
- SwissProt: P14210 Human
- Unigene: 396530 Human
- Unigene: 561679 Human
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Alternative names
- DFNB39 antibody
- F TCF antibody
- Fibroblast derived tumor cytotoxic factor antibody
see all
Images
Datasheets and documents
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Datasheet download
References (7)
ab24865 has been referenced in 7 publications.
- Du T et al. Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor. Hum Cell 34:1103-1113 (2021). PubMed: 33860459
- Wen Q et al. 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells. BMC Cancer 19:224 (2019). PubMed: 30866863
- Kogata Y et al. Foretinib (GSK1363089) induces p53-dependent apoptosis in endometrial cancer. Oncotarget 9:22769-22784 (2018). PubMed: 29854314
- Cao XF et al. Therapeutic effects of hepatocyte growth factor-overexpressing dental pulp stem cells on liver cirrhosis in a rat model. Sci Rep 7:15812 (2017). PubMed: 29150644
- Ono YJ et al. Estradiol-mediated hepatocyte growth factor is involved in the implantation of endometriotic cells via the mesothelial-to-mesenchymal transition in the peritoneum. Am J Physiol Endocrinol Metab 308:E950-9 (2015). PubMed: 25852006
- Cohen ME et al. Signaling through three chemokine receptors triggers the migration of transplanted neural precursor cells in a model of multiple sclerosis. Stem Cell Res 13:227-39 (2014). IHC-FoFr ; Mouse . PubMed: 25086214
- Goldoni S et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol 185:743-54 (2009). WB ; Human . PubMed: 19433454