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Overview

  • Product nameAnti-MRP1 antibody [QCRL1]See all MRP1 primary antibodies ...
  • Description
    Mouse monoclonal [QCRL1] to MRP1
  • SpecificityReacts with MRP. This antibody does not cross-react with the human MDR1 and MDR3, or mouse MRP gene products
  • Tested applicationsICC, IHC-P, IHC-Fr, WB more details
  • Species reactivity
    Reacts with: Human

    Does not react with

    Mouse
  • Immunogen

    Membranes prepared from the human small cell lung cancer cell line H68AR.

  • EpitopeReacts with a linear epitope
  • Positive controlCell Lines: Drug-sensitive parental cell lines and their multidrug-resistant derivatives

Applications

Our Abpromise guarantee covers the use of ab3369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC ICC: Use at an assay dependent dilution.
IHC-P IHC-P: Use at an assay dependent dilution.
IHC-Fr IHC-Fr: Use at an assay dependent dilution.
WB WB: Use at an assay dependent dilution. Predicted molecular weight: 190 kDa.

Target

  • FunctionMediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
  • Tissue specificityLung, testis and peripheral blood mononuclear cells.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localizationCell membrane.

    • Target information above from: UniProt accession P33527 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        ABC 29 antibodyABC29 antibodyABCC 1 antibody
        ABCC antibodyABCC1 antibodyATP binding cassette sub family C (CFTR/MRP) member 1 antibodyATP binding cassette sub-family C member 1 antibodyATP-binding cassette sub-family C member 1 antibodyDKFZp686N04233 antibodyDKFZp781G125 antibodyGS X antibodyGSX antibodyLeukotriene C(4) transporter antibodyLTC4 transporter antibodyMRP 1 antibodyMRP antibodyMRP1_HUMAN antibodyMultidrug resistance associated protein 1 antibodyMultidrug resistance protein antibodyMultidrug resistance-associated protein 1 antibodyMultiple drug resistance associated protein antibodyMultiple drug resistance protein 1 antibody
      see all

    References for Anti-MRP1 antibody [QCRL1] (ab3369)

    This product has been referenced in:
    • Rivers F  et al. Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations. Eur J Pharmacol 598:1-8 (2008). WB ; Human . Read more (PubMed: 18835265) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"