Anti-Kif2a antibody (ab3475)
Key features and details
- Rabbit polyclonal to Kif2a
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Kif2a antibody
See all Kif2a primary antibodies -
Description
Rabbit polyclonal to Kif2a -
Host species
Rabbit -
Specificity
Detects Kinesin 2 (Kif2a) from mouse tissues. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Chicken, Cow, Human, Xenopus laevis, Orangutan -
Immunogen
Synthetic peptide corresponding to Mouse Kif2a aa 1-11.
Sequence:MVTSLNEDNES
(Peptide available asab4992) -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab3475 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 79 kDa.
This antibody detects a ~95 kDa protein representing KIF 2 from mouse brain homogenate. |
Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 79 kDa. This antibody detects a ~95 kDa protein representing KIF 2 from mouse brain homogenate. |
Target
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Function
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. -
Sequence similarities
Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
Contains 1 kinesin-motor domain. -
Cellular localization
Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > spindle. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1. - Information by UniProt
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Database links
- Entrez Gene: 3796 Human
- Entrez Gene: 16563 Mouse
- Entrez Gene: 84391 Rat
- Entrez Gene: 379622 Xenopus laevis
- Omim: 602591 Human
- SwissProt: O00139 Human
- SwissProt: P28740 Mouse
- SwissProt: Q9WV63 Rat
see all -
Alternative names
- CDCBM3 antibody
- HK2 antibody
- KIF2 antibody
see all
Datasheets and documents
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Datasheet download
References (1)
ab3475 has been referenced in 1 publication.
- Patel M et al. Osteopontin and LDLR Are Upregulated in Hearts of Sudden Cardiac Death Victims With Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus. Front Cardiovasc Med 7:610282 (2020). PubMed: 33330671