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Overview

  • Product nameAnti-SOX9 antibodySee all SOX9 primary antibodies ...
  • Description
    Rabbit polyclonal to SOX9
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to N terminal amino acids 1-150 of Human SOX9

  • Positive controlSW480 cells. Human testis.

Applications

Our Abpromise guarantee covers the use of ab36748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: 1/50.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionPlays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
    • Involvement in diseaseDefects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.
    • Sequence similaritiesContains 1 HMG box DNA-binding domain.
    • Cellular localizationNucleus.

      • Target information above from: UniProt accession P48436 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          campomelic dysplasia autosomal sex reversal antibodyCMD 1 antibodyCMD1 antibody
          CMPD 1 antibodyCMPD1 antibodySOX 9 antibodySox9 antibodySOX9_HUMAN antibodySRA 1 antibodySRA1 antibodySRY (sex determining region Y) box 9 (campomelic dysplasia autosomal antibodySRY (sex determining region Y) box 9 antibodySRY (sex determining region Y)-box 9 antibodySRY (sex-determining region Y)-box 9 protein antibodyTranscription factor SOX 9 antibodyTranscription factor SOX-9 antibodytranscription factor SOX9 antibody
        see all

      Anti-SOX9 antibody images

      • Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - SOX9 antibody (ab36748)
        Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - SOX9 antibody (ab36748)
        Human testis stained with Anti-SOX9 (ab36748) at 1/50 dilution by Immunohistochemistry (FFPE-sections) for 30 min at room temperature.

      References for Anti-SOX9 antibody (ab36748)

      This product has been referenced in:

      See 1 Publication for this product

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