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| Product Name | MMP19 antibody - Carboxyterminal end |
| | See all MMP19 antibodies (9)... |
| Product type | Primary antibodies |
| Description | Rabbit polyclonal to MMP19 - Carboxyterminal end |
| Immunogen | Synthetic peptide corresponding to the carboxyterminal end of human MMP19.
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| Reacts with
(species key) | Hu |
| Specificity | ab39029 recognises the Carboxyterminal end of MMP19. It does not recognise the smallest active form of MMP19 as the hemopexin domain is cleaved from it.
This antibody will bind to the reduced and non reduced form of MMP19, but does not cross react with the other MMP family members (MMP1, MMP2, MMP3, MMP9, etc.) We have a range of domain specific antibodies for this target. For a full list please see all MMP19 antibodies |
| Tested applications
(see key) | WB |
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| Abreviews | |
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| Application notes
(see key) | Recommended dilutions
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT - 1/5000 when using chemiluminescent substrates. Predicted molecular weight: 57 kDa. When used against the reduced protein, ab39029 identifies bands at 58 Kd, 45 Kd, and a series of further cleaved active forms. Note: the conditioned media may need to be concentrated for Western blot. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Cellular localization | Secreted |
| Research areas | Cancer >> Tumor biomarkers >> Enzymes >> MMPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> MMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> MMPs
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP |
| Relevance | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP19 is one of the more recently identified MMPs, has several novel structural features, and so does not fall into the traditional MMP groupings. It is without a furin cleavage site or transmembrane domain and unlike the other MMPs, MMP19 has an 8-residue acidic patch at the beginning of the hinge region. MMP19 is not constituitively produced by most cell types; it has been found in lung fibroblasts, and gingival fibroblasts when stimulated with TPA, as well as breast tumor and osteosarcoma cell lines. MMP19 may play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigens to anti-MMP19 are frequent in RA patients. |
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| Database links | The links below go to external sites and will open in a new browser window | SwissProt | | Q99542 (Human)
| Unigene | | |
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