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| Product Name | ADAMTS1 antibody - Propeptide domain |
| | See all ADAMTS1 antibodies (3)... |
| Product type | Primary antibodies |
| Description | Rabbit polyclonal to ADAMTS1 - Propeptide domain |
| Immunogen | This antibody is made to a synthetic peptide based on the Propeptide domain of human ADAMTS1. |
| Reacts with
(species key) | Hu |
| Specificity | We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS1 antibodies |
| Epitope | This antibody recognizes the first 30 amino acids of the protein. |
| Tested applications
(see key) | WB |
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| Abreviews | |
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| Application notes
(see key) | Recommended dilutions
WB: Use at an assay dependent dilution. Predicted molecular weight: 105 kDa. A recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Ab39195 recognizes the zymogen of ADAMTS1 at 110-120 kD in reduced Western blots, but not the furin cleaved ADAMTS1. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Cellular localization | Secreted. Associated with the extracellular matrix (By similarity). |
| Research areas | Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP |
| Relevance | ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function.
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| Database links | The links below go to external sites and will open in a new browser window |
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