| · Glycerol MSDS · Sodium Azide MSDS | |
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| Product Name | MMP3 protein |
| Product type | Proteins and Peptides |
| Peptide | Full length native protein (purified) of Human MMP3.This Protein was used as an immunogen for ab38912 - MMP3 antibody - Whole molecule. |
| Specificity | We have a range of domain specific antibodies for this target. For a full list please see all MMP3 antibodies |
| Tested applications
(see key) | EIA-Ctrl, SDS-PAGE, WB |
| Application notes
(see key) | Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
WB: The zymogen runs as 59 and 57 kDa bands, representing the glycosylated and non-glycosylated forms. Active enzyme runs at 45 kDa, and breaks down stepwise to a 28 kDa form. The enzyme is supplied as a mixture of the zymogen and active enzyme. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Research areas | Cardiovascular >> Atherosclerosis >> Thrombosis >> Other
Cancer >> Tumor biomarkers >> Enzymes >> MMPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> MMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> MMPs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP |
| Relevance | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer. |
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| Storage buffer | The enzyme is supplied as a mixture of the zymogen and active enzyme in:
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 25mM Tris, pH 7.4 Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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| Purification notes | This protein purified from human fibroblast is free of endogenous inhibitors, TIMP1 and TIMP2, and other matrix metalloproteinases. |
| Form | Liquid |
| Concentration | 0.100 mg/ml |
| Storage instructions | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MMP3 protein is on this datasheet. But please do contact us if you would like any reassurance! |
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