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| | Western blot - Kallikrein 15 antibody - Catalytic domain (ab40961)
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| Product Name | Kallikrein 15 antibody - Catalytic domain |
| | See all Kallikrein 15 antibodies (4)... |
| Product type | Primary antibodies |
| Description | Rabbit polyclonal to Kallikrein 15 - Catalytic domain |
| Immunogen | Synthetic peptide based on the catalytic domain of human Kallikrein 15.
(Peptide available as ab43112.) |
| Reacts with
(species key) | Hu |
| Specificity | ab40961 reacts with human kallikrein 15 and does not react with the human kallikreins (hK1-14). We have a range of domain specific antibodies for this target. For a full list please see all Kallikrein 15 antibodies |
| Tested applications
(see key) | WB |
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| Abreviews | |
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| Application notes
(see key) | Recommended dilutions
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 28 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Cellular localization | Secreted |
| Research areas | Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins |
| Relevance | The human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp, and Ser residues, typically five coding exons, and varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N-terminal peptide, and all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions and have key roles in many physiological and pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection and characterization of many forms of cancer.
Kallikrein 15 is one of the fifteen kallikrein subfamily members whose gene is located in a cluster on chromosome 19. Increased levels are found in prostate cancer, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. Four splice variants, each encoding a distinct isoform, have been described.
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| Database links | The links below go to external sites and will open in a new browser window |
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