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MMP1 peptide (Propeptide domain) (ab41021)

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Overview

  • Product nameMMP1 peptide (Propeptide domain)See all MMP1 proteins and peptides ...
  • Protein descriptionSynthetic peptide MMP1. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab38924 - MMP1 antibody - Propeptide domain.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41021 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab38924. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        27 kDa interstitial collagenaseCLGCLGN
        CLGNcollagenase, fibroblastcollagenase, interstitialFibroblast collagenaseInterstitial collagenaseInterstitial collagenase precursorMatrix metallopeptidase 1 (interstitial collagenase)Matrix metalloprotease 1Matrix Metalloproteinase 1Matrix metalloproteinase-1MM01MMP 1MMP-1MMP1MMP1_HUMANOTTHUMP00000045866
      see all
  • FunctionCleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThere are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P03956 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP1 peptide (Propeptide domain) (ab41021)

    ab41021 has not yet been referenced specifically in any publications.

    Publishing research using ab41021 ? Please let us know so that we can cite the reference in this datasheet

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    Dear abcam webmaster:   i want to by this production from your company, but, i have some question on this MMP1 peptide. MMP1 peptide (Propeptide domain) (ab41021) if this mmp1 peptide is a mmp1 blocking peptide. or if use this MMP1 peptide tr...

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    Thank you for your enquiry and your interest in our products. This peptide (ab41021) was used as an immunogen for ab38924 - MMP1 antibody (propeptide domain). As the datasheet indicates it has been tested in ELISA and Western blot application - bu...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"