MMP1 peptide (Propeptide domain) (ab41021)
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Our Abpromise guarantee covers the use of ab41021 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 27 kDa interstitial collagenaseCLGCLGN
- CLGNcollagenase, fibroblastcollagenase, interstitialFibroblast collagenaseInterstitial collagenaseInterstitial collagenase precursorMatrix metallopeptidase 1 (interstitial collagenase)Matrix metalloprotease 1Matrix Metalloproteinase 1Matrix metalloproteinase-1MM01MMP 1MMP-1MMP1MMP1_HUMANOTTHUMP00000045866
Contains 4 hemopexin-like domains.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
modificationsUndergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
References for MMP1 peptide (Propeptide domain) (ab41021)
ab41021 has not yet been referenced specifically in any publications.