ADAM17 peptide (Activation site) (ab41215)
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Our Abpromise guarantee covers the use of ab41215 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- A disintegrin and metalloproteinase domain 17A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)ADA17_HUMAN
- ADAM 17ADAM metallopeptidase domain 17ADAM17ADAM17 proteinCD 156bCD156bCD156b antigenCSVPDisintegrin and metalloproteinase domain-containing protein 17MGC71942Snake venom like proteaseSnake venom-like proteaseTACETNF alpha convertaseTNF alpha converting enzymeTNF-alpha convertaseTNF-alpha-converting enzymeTumor Necrosis Factor Alpha Converting Enzyme
Contains 1 peptidase M12B domain.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
modificationsThe precursor is cleaved by a furin endopeptidase.
Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
References for ADAM17 peptide (Activation site) (ab41215)
ab41215 has not yet been referenced specifically in any publications.