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ADAM20 peptide (Catalytic domain) (ab41221)

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Overview

  • Product nameADAM20 peptide (Catalytic domain)See all ADAM20 proteins and peptides ...
  • Protein descriptionSynthetic peptide ADAM20. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab28295 - ADAM20 antibody - Catalytic domain.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41221 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28295. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        A disintegrin and metalloproteinase domain 20A disintegrin and metalloproteinase domain 20 preproproteinADA20_HUMAN
        ADAM 20ADAM metallopeptidase domain 20ADAM20Disintegrin and metalloproteinase domain-containing protein 20EC 3.4.24.OTTHUMP00000236151
      see all
  • FunctionMay be involved in sperm maturation and/or fertilization.
  • Tissue specificityTestis specific.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • DomainA tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession O43506 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAM20 peptide (Catalytic domain) (ab41221)

    ab41221 has not yet been referenced specifically in any publications.

    Publishing research using ab41221 ? Please let us know so that we can cite the reference in this datasheet

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