You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Insulin degrading enzyme / IDE peptide (Mid molecule) (ab41260)

Submit an Abreview Submit a Question

Overview

  • Product nameInsulin degrading enzyme / IDE peptide (Mid molecule)See all Insulin degrading enzyme / IDE proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab28562 - Insulin degrading enzyme / IDE antibody.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41260 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    ELISA
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28562. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Abeta-degrading proteaseFLJ35968Ide
        IDE_HUMANinsulin proteaseInsulin-degrading enzymeinsulinaseinsulysinOTTHUMP00000020097
      see all
  • FunctionPlays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
  • Sequence similaritiesBelongs to the peptidase M16 family.
  • Post-translational
    modifications    The N-terminus is blocked.
  • Cellular localizationCytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

    • Target information above from: UniProt accession P14735 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Insulin degrading enzyme / IDE peptide (Mid molecule) (ab41260)

    ab41260 has not yet been referenced specifically in any publications.

    Publishing research using ab41260 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit a Question for ab41260

    There are currently no Questions for ab41260.
    Please use the link above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"