Anti-NOR1 antibody [H7833] (ab41918)

Overview

• Product nameAnti-NOR1 antibody [H7833]See all NOR1 primary antibodies ...
• Description
  Mouse monoclonal [H7833] to NOR1
• SpecificityThis antibody specifically recognizes human NGFIB gamma but does not recognize human NGFIB alpha and beta.
• Tested applicationsWB, ELISA, IP more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment: PCVQAQYSPS PPGSSYAAQT YSSEYTTEIM NPDYTKLTMD LGSTEITATA TTSLPSISTF VEGYSSNYEL KPSCVYQMQR PLIKVEEGRA PSYH, corresponding to amino acids 2-95 of Human NOR1

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPhysiological saline. Preservative: 0.1% Sodium Azide
  
• Concentration information loading...
• Purification notesPurified from ascites via ammonium sulfate fractionation,
• Clonality Monoclonal
• Clone numberH7833
• IsotypeIgG2a
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Orphan Nuclear Receptors

  • Neuroscience
  • Neurology process
  • Neurogenesis

Applications

Target

• FunctionBinds to the B1A response-element.
• Tissue specificityIsoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
• Involvement in diseaseDefects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
  Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
• Sequence similaritiesBelongs to the nuclear hormone receptor family. NR4 subfamily.
  Contains 1 nuclear receptor DNA-binding domain.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q92570 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 8013 Human
  • Omim: 600542 Human
  • SwissProt: Q92570 Human
  • Unigene: 279522 Human

• Alternative names
  CHN antibodyChondrosarcoma, extraskeletal myxoid, fused to EWS antibodyCSMF antibody

  MINOR antibodyMitogen induced nuclear orphan receptor antibodyMitogen-induced nuclear orphan receptor antibodyNeuron derived orphan receptor 1 antibodyNeuron derived orphan receptor antibodyNeuron-derived orphan receptor 1 antibodyNOR1 antibodyNr4a3 antibodyNR4A3_HUMAN antibodyNuclear hormone receptor NOR-1 antibodyNuclear hormone receptor NOR1 antibodyNuclear receptor subfamily 4 group A member 3 antibodyTEC antibodyTranslocated in extraskeletal chondrosarcoma antibody

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Anti-NOR1 antibody [H7833] images

• 

  Western blot - NOR1 antibody [H7833] (ab41918)
  Anti-NOR1 antibody [H7833] (ab41918) at 1 µg/ml + whole cell lysate prepared from human macrophages at 20 µg/ml
  
  Secondary
  HRP conjugated rabbit monoclonal at 1/500 dilution
  developed using the ECL technique
  
  Predicted band size : 68 kDa
  Observed band size : 70 kDa (why is the actual band size different from the predicted?)
  
  
  Exposure time : 15 seconds

  Image courtesy of an anonymous Abreview.

  See Abreview