· Glycerol MSDS
· Sodium Azide MSDS
| | Western blot - PCSK9 antibody - Propeptide domain (ab42085)
(enlarge)
| |
|
| Product Name | PCSK9 antibody - Propeptide domain |
| | See all PCSK9 antibodies (6)... |
| Product type | Primary antibodies |
| Description | Rabbit polyclonal to PCSK9 - Propeptide domain |
| Immunogen | Synthetic peptide corresponding to the propeptide domain of Human PCSK9.
(the amino acid sequence is considered proprietary)(Peptide available as ab44562.) |
| Reacts with
(species key) | Hu |
| Specificity | ab42085 recognises PCSK9 in teh region corresponding to the propeptide cleave site, and detects both the zymogen and active PCSK9. We have a range of domain specific antibodies for this target. For a full list please see all PCSK9 antibodies |
| Tested applications
(see key) | WB |
|
| Abreviews | |
|
| Application notes
(see key) | Recommended dilutions
WB: 1/1000 - 1/5000. Predicted molecular weights: ~15 and 74 kDa. Recommended starting dilution 1/1000 with colourimetric substrates, 1:5000 with chemiluminescent substrates. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Cellular localization | Secreted |
| Research areas | Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases
Signal Transduction >> Metabolism >> Lipid metabolism
Stem Cells >> Neural Stem Cells >> Intracellular
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Signal Transduction >> Metabolism >> Amino Acids |
| Relevance | PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 may function as a proprotein convertase. PCSK9 plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in PCSK9 gene have been associated with a third form of autosomal dominant familial hypercholesterolemia. |
| | |
| Database links | The links below go to external sites and will open in a new browser window |
my account
basket
help
contact us
Datasheet
References (0)
