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Overview

  • Product nameAnti-Cholecystokinin 8 antibodySee all Cholecystokinin 8 primary antibodies ...
  • Description
    Rabbit polyclonal to Cholecystokinin 8
  • Tested applicationsICC/IF, IHC-Fr more details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide: VEAVDPME conjugated to Bovine thyroglobulin by a Glutaraldehyde linker, corresponding to amino acids 26/33 of Cholecystokinin 8. (Sequence homologous to rat and many other species)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlRat hypothalamus and spinal cord

Properties

Applications

Our Abpromise guarantee covers the use of ab43842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF
IHC-Fr
  • Application notesICC/IF: 1/100 - 1/200.
    IHC-Fr: 1/500 - 1/1000.
    Note: sample need to be fixed in paraformaldehyde.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceCholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo.
    • Cellular localizationSecreted
    • Database links
      • Alternative names
          CCK antibodyCCK8 antibodyCholecystokinin 8 antibody
          Cholecystokinin antibodyCholecystokinin preproprotein antibodyProcholecystokinin precursor antibody
        see all

      Anti-Cholecystokinin 8 antibody images

      • Immunohistochemistry (Frozen sections) - Cholecystokinin 8 antibody (ab43842)
        Immunohistochemistry (Frozen sections) - Cholecystokinin 8 antibody (ab43842)
        Cholecystokinin 8 terminals and fibers in rat dorsal horn (spinal cord), vibratome sections, ABC detection.

      References for Anti-Cholecystokinin 8 antibody (ab43842)

      This product has been referenced in:
      • Hu W  et al. Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network. Neuropsychopharmacology 35:1693-707 (2010). Read more (PubMed: 20357756) »

      See 1 Publication for this product

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"