Overview
Product nameCalpain 10 peptideSee all Calpain 10 proteins and peptides ...
Protein descriptionSynthetic peptide Calpain 10.
(Note: the amino acid sequence is proprietary)
This peptide was used as an immunogen for ab28222 - Calpain 10 antibody - Aminoterminal end domain I.
Properties
Purity> 95
% by SDS-PAGE
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab44842
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| ELISA |
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| WB |
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Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28222. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Protein info
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Alternative names
Calcium activated neutral proteaseCalcium activated neutral proteinase 10Calcium-activated neutral proteinase 10
calpain like protease CAPN10Calpain-10Calpain10CAN10_HUMANCANP 10CANP10CAPN 10CAPN10EC 3.4.22.KIAA1845NIDDM1
see all
FunctionCalcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Tissue specificityUbiquitous.
Involvement in diseaseDefects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1) [MIM:601283]. It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Sequence similaritiesBelongs to the peptidase C2 family.
Contains 1 calpain catalytic domain.
References for Calpain 10 peptide (ab44842)
ab44842
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
