Anti-TGF beta 1 antibody [TGFB17] (ab49574)
- Product nameAnti-TGF beta 1 antibody [TGFB17]See all TGF beta 1 primary antibodies ...
- DescriptionMouse monoclonal [TGFB17] to TGF beta 1
- SpecificityMay crossreact with other members of the TGFB family.
- Tested applicationsIHC-P more details
- Species reactivityReacts with: Human
Prokaryotic recombinant protein corresponding to the full length mature transforming growth factor beta 1 molecule.
- Positive controlPlacenta.
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 15mM Sodium Azide
Constituents: Tissue culture supernatant
- PurityTissue culture supernatant
- Clonality Monoclonal
- Clone numberTGFB17
Our Abpromise guarantee covers the use of ab49574 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: 1/20 - 1/40. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
- FunctionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
- Tissue specificityHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
- Involvement in diseaseDefects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
- Sequence similaritiesBelongs to the TGF-beta family.
The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
- Cellular localizationSecreted > extracellular space > extracellular matrix.
- CED antibodyDPD1 antibodyLAP antibody
- Latency-associated peptide antibodyTGF beta 1 antibodyTGF beta antibodyTGF beta 1 protein antibodyTGF-beta 1 protein antibodyTGF-beta-1 antibodyTGF-beta-5 antibodyTGF-beta1 antibodyTGFB antibodyTgfb-1 antibodyTGFB1 antibodyTGFB1_HUMAN antibodyTGFbeta antibodyTGFbeta1 antibodyTransforming Growth Factor b1 antibodyTransforming Growth Factor beta 1 antibodyTransforming growth factor beta 1a antibodytransforming growth factor beta-1 antibodyTransforming growth factor beta-1 precursor antibodytransforming growth factor, beta 1 antibody
Anti-TGF beta 1 antibody [TGFB17] images
Human breast carcinoma: immunohistochemical staining for Transforming Growth Factor Beta 1 using 1/20 ab49574. Note cytoplasmic staining of tumor cells. Paraffin section.