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Overview

  • Product nameWISP1 protein (Active)See all WISP1 proteins and peptides ...
  • Protein descriptionRecombinant Human WISP1, a 38.1 kDa protein containing 346 amino acid residues. It is composed of four distinct structural domains; the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cystine knot-like (CTCK) domain.
  • Expression hostE. coli

    • Properties

  • Purification notesGreater than 98% by SDS-PAGE gel and HPLC analyses Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • Biological activityBiological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
  • FormLyophilised:Reconstitute product with 10mM Acetic Acid.
  • Storage instructionsThe lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 10mM Acetic acid
  • Concentration information loading...
  • Sequence notesTALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab50041 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    Functional Studies FuncS: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab10737,ab60114,ab65943 and ab155654.

    • Protein info

    • Alternative names
        CCN 4CCN family member 4CCN4
        WISP 1WISP 1cWISP 1iWISP 1tcWISP1cWISP1iWISP1tcWnt 1 induced secreted proteinWNT 1 induced secreted protein 1WNT 1 inducible signaling pathway protein 1Wnt 1 signaling pathway protein 1Wnt-1 inducible signaling pathway protein 1Wnt1 induced secreted proteinWNT1 induced secreted protein 1WNT1 inducible signaling pathway protein 1Wnt1 signaling pathway protein 1WNT1-inducible-signaling pathway protein 1
      see all
  • RelevanceWISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
  • Cellular localizationSecreted

    • References for WISP1 protein (Active) (ab50041)

    ab50041 has not yet been referenced specifically in any publications.

    Publishing research using ab50041 ? Please let us know so that we can cite the reference in this datasheet

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