Anti-Acinus antibody [2005C3a] (ab50827)

Overview

• Product nameAnti-Acinus antibody [2005C3a]See all Acinus primary antibodies ...
• Description
  Mouse monoclonal [2005C3a] to Acinus
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant human Acinus fragment carrying 50-200 aa

• Positive controlrecombinant immunozing fragment

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 1% BSA, PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesab50827 was purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum, and it was filter sterilized.
• Clonality Monoclonal
• Clone number2005C3a
• IsotypeIgG1
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Chromatin condensation

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Apoptosis
  • Nuclear

  • Cell Biology
  • Apoptosis
  • Nucleus
  • Chromatin Condensation

Applications

Target

• FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
• Tissue specificityUbiquitous.
• Sequence similaritiesContains 1 SAP domain.
• Post-translational
  modificationsUndergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q9UKV3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 22985 Human
  • Entrez Gene: 22985 Human
  • Omim: 604562 Human
  • SwissProt: Q9UKV3 Human
  • SwissProt: Q9UKV3 Human
  • Unigene: 124490 Human

• Alternative names
  ACIN 1 antibodyACIN1 antibodyACINU_HUMAN antibody

  ACINUS antibodyACN antibodyApoptotic chromatin condensation inducer 1 antibodyApoptotic chromatin condensation inducer in the nucleus antibodyDKFZp667N107 antibodyfSAP152 antibodyfunctional spliceosome-associated protein 152 antibodyKIAA0670 antibody

  see all

Anti-Acinus antibody [2005C3a] images

• 

  Western blot - Acinus antibody [2005C3a] (ab50827)
  Anti-Acinus antibody [2005C3a] (ab50827) at 1/50 dilution + A2058 whole cell lysate at 50 µg
  
  Secondary
  anti-mouse IgG at 1/2500 dilution
  
  Predicted band size : 152 kDa