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Overview

  • Product nameIGF1 protein (Rat)See all IGF1 proteins and peptides ...
  • Protein descriptionRecombinant rat IGF-I is a 7.69 kDa protein containing 70 amino acid residues.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesGreater than 95% by SDS-PAGE and HPLC analyses.
  • FormLyophilised:Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Endotoxin level is <0.1 ng per µg of IGF-I.
  • Concentration information loading...
  • Additional notesThis solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. The lyophilized IGF-I is best-stored desiccated below 0°C. Reconstituted IGF-I should be stored at working aliquots at -20°C.
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab52006 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution. The ED50 was determined by two methods: 1) By stimulation of protein synthesis in rat L6 myoblasts, the ED50 was found to be <30 ng/ml; 2) By Type I IGF receptor binding assay, the ED50 was found to be <10 ng/ml.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        IBP1IGF IIGF IA
        IGF IBIGF-IIgf1IGF1_HUMANIGFIIGFIAInsulin like growth factor 1Insulin like growth factor 1 (somatomedin C)Insulin like growth factor IAInsulin like growth factor IBInsulin-like growth factor IMechano growth factorMGFOTTHUMP00000195080OTTHUMP00000195081OTTHUMP00000195082OTTHUMP00000195083OTTHUMP00000195084Somatomedin CSomatomedin-C
      see all
  • FunctionThe insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
  • Involvement in diseaseDefects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
  • Sequence similaritiesBelongs to the insulin family.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P05019 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for IGF1 protein (Rat) (ab52006)

    ab52006 has not yet been referenced specifically in any publications.

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