You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameIL6 protein (His tag)See all IL6 proteins and peptides ...
  • Protein descriptionRecombinant fusion protein, corresponding to amino acids 29-211 of Human mature IL6 with an N terminal hexahistidine tag, (184 amino acids).
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab53327 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Interleukin BSF 2B cell differentiation factorB cell stimulatory factor 2
        B-cell stimulatory factor 2BSF 2BSF-2BSF2CDFCTL differentiation factorCytotoxic T cell differentiation factorHepatocyte stimulating factorHGFHPGFHSFHybridoma growth factorHybridoma growth factor Interferon beta-2Hybridoma plasmacytoma growth factorIFN-beta-2IFNB2IL 6IL-6IL6IL6 proteinIL6_HUMANInterferon beta 2Interferon beta-2Interleukin 6Interleukin 6 (interferon beta 2)Interleukin-6Interleukin6
      see all
  • FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
  • Involvement in diseaseGenetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
  • Sequence similaritiesBelongs to the IL-6 superfamily.
  • Post-translational
    modifications    N- and O-glycosylated.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P05231 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    IL6 protein (His tag) images

    • SDS-PAGE - IL6 protein (His tag) (ab53327)
      SDS-PAGE - IL6 protein (His tag) (ab53327)

    References for IL6 protein (His tag) (ab53327)

    ab53327 has not yet been referenced specifically in any publications.

    Publishing research using ab53327 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab53327

    There are currently no Abreviews for ab53327.
    Please use the link above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"