Anti-SECISBP2 antibody (ab53534)

Overview

• Product nameAnti-SECISBP2 antibodySee all SECISBP2 primary antibodies ...
• Description
  Goat polyclonal to SECISBP2
• Tested applicationsWB, ICC/IF, IP, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Cow, Dog, Pig
• Immunogen

  Synthetic peptide: C-KERQERKQRLQEN, corresponding to internal sequence amino acids 538-550 of Human SECISBP2

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Nucleotide metabolism
  • Purine and pyrimidine synthesis

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Signal Transduction
  • Metabolism
  • Amino Acids

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • Translation
  • Regulation

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Other

  • Cell Biology
  • Other Antibodies
  • Oxidative Stress

Applications

Target

• FunctionBinds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
• Tissue specificityExpressed at high levels in testis.
• Involvement in diseaseDefects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q96T21 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 511202 Cow
  • Entrez Gene: 476351 Dog
  • Entrez Gene: 79048 Human
  • Entrez Gene: 79048 Human
  • Omim: 607693 Human
  • SwissProt: Q96T21 Human
  • SwissProt: Q96T21 Human
  • Unigene: 59804 Human

• Alternative names
  DKFZp686C09169 antibodyOTTHUMP00000064929 antibodyOTTHUMP00000064930 antibody

  OTTHUMP00000064931 antibodyOTTHUMP00000064932 antibodyRP11 89K14.1 antibodySBP 2 antibodySBP2 antibodySEBP2_HUMAN antibodySECIS binding protein 2 antibodySECIS-binding protein 2 antibodySECISBP 2 antibodySECISBP2 antibodySelenocysteine insertion sequence binding protein 2 antibodySelenocysteine insertion sequence-binding protein 2 antibody

  see all

Anti-SECISBP2 antibody images

• 

  Western blot - SECISBP2 antibody (ab53534)
  All lanes : Anti-SECISBP2 antibody (ab53534) at 1/5000 dilution
  
  Lane 1 : Mouse testis lysate - cytosolic fraction (50µg)
  Lane 2 : Mouse testis lysate - cytosolic fraction (50µg)
  Lane 3 : Mouse liver lysate - cytosolic fraction (50µg)
  Lane 4 : Mouse kidney lysate - cytosolic fraction (50µg)
  Lane 5 : Mouse brain lysate - cytosolic fraction (50µg)
  Lane 6 : Mouse brain lysate - cytosolic fraction (50µg)
  Lane 7 : Human HepG2 Lysate - cytosolic fraction (50µg)
  Lane 8 : Rat testis lysate - cytosolic fraction (50µg)
  
  Secondary
  Donkey anti-goat conjugated to HRP
  
  Predicted band size : 95 kDa
  

  This image is courtesy of an anonymous Abreview

  See Abreview

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SECISBP2 antibody (ab53534)

  ab53534 at 3ug/ml staining SECISBP2 in human testis tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). The tissue underwent antigen retrieval in microwave with Tris/EDTA buffer (pH 9). The HRP-staining procedure was used for detection.