Anti-IL23 Receptor antibody - Aminoterminal end (ab53656)
Overview
- Product nameAnti-IL23 Receptor antibody - Aminoterminal endSee all IL23 Receptor primary antibodies ...
- DescriptionGoat polyclonal to IL23 Receptor - Aminoterminal end
- Tested applicationsWB, ICC, IHC-P more details
- Species reactivityReacts with: Mouse, Human
Predicted to work with: Pig - Immunogen
Synthetic peptide: CQPRKLHFYKNGIKERFQITRINKTTARL, corresponding to N terminal amino acids 59-87 of Human IL23 Receptor Note: Peptide sequence is <50% identical to other receptors in this region.
- Positive controlHuman and Mouse spleen paraffin sections.
Properties
- FormLiquid
- Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.1% Sodium Azide
Constituents: PBS, 1mg/ml BSA, pH 7.2 -
Concentration information loading... - PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab53656 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | |
| ICC | |
| IHC-P |
IHC-P: 1/250.
WB: 1/1000. Predicted molecular weight: 72 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
- FunctionAssociates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
- Tissue specificityExpressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
- Involvement in diseaseGenetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. - Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 2 fibronectin type-III domains. - Post-translational
modificationsPhosphorylated in response to IL23. - Cellular localizationCell membrane.
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Database links
- Entrez Gene: 149233 Human
- Entrez Gene: 209590 Mouse
- Omim: 607562 Human
- SwissProt: Q5VWK5 Human
- SwissProt: Q8K4B4 Mouse
- Unigene: 677426 Human
- Unigene: 221227 Mouse
Target information above from: UniProt accession
Q5VWK5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- IL 23R antibodyIL-23 receptor antibodyIL-23R antibody
- IL23R antibodyIL23R_HUMAN antibodyInterleukin 23 receptor antibodyInterleukin-23 receptor antibody
see all
Anti-IL23 Receptor antibody - Aminoterminal end images
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Immunohistochemistry (Paraffin-embedded sections) - IL23 Receptor antibody - Aminoterminal end (ab53656)ab53656 at 1/250 dilution staining IL23 Receptor in human spleen by Immunohistochemistry, Paraffin embedded tissue. -
Immunohistochemistry (Paraffin-embedded sections) - IL23 Receptor antibody - Aminoterminal end (ab53656)ab53656 at 1/250 dilution staining IL23 Receptor in mouse spleen by Immunohistochemistry, Paraffin embedded tissue. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - IL23 Receptor antibody - Aminoterminal end (ab53656)This image is courtesy of an Abreview submitted by Nicole Schechterab53656 staining IL23 in human colon by immunohistochemistry (formalin/PFA-fixed paraffin-embedded sections). Cells were formaldehyde fixed prior to blocking in 10% serum for 2 hours at 21°C. The primary antibody was diluted 1/200 and incubated with the sample for 2 hours at 21°C. Alexa fluor® 594 rabbit polyclonal was used as the secondary.
References for Anti-IL23 Receptor antibody - Aminoterminal end (ab53656)
This product has been referenced in:
- Janssen CE et al. Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2-related disorders Blau syndrome and Crohn disease. J Allergy Clin Immunol 129:1076-84 (2012). IHC-P ; Human . Read more (PubMed: 22464675) »
- Baker DA et al. Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. J Immunol 185:2570-9 (2010). IHC-P ; Mouse . Read more (PubMed: 20644167) »
