Anti-alpha 1 Antichymotrypsin antibody (ab54693)

Overview

• Product nameAnti-alpha 1 Antichymotrypsin antibodySee all alpha 1 Antichymotrypsin primary antibodies ...
• Description
  Mouse monoclonal to alpha 1 Antichymotrypsin
• Tested applicationsIHC-P, WB, Sandwich ELISA more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Human, Gorilla, Dictyostelium discoideum
• Immunogen

  Recombinant full length protein, corresponding to amino acids 25-424 of Human alpha 1 Antichymotrypsin

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Proteases

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteolytic enzymes
  • Other proteases

Applications

Target

• FunctionAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
• Tissue specificityPlasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
• Involvement in diseaseDefects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
• Sequence similaritiesBelongs to the serpin family.
• DomainThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
• Cellular localizationSecreted.

Target information above from: UniProt accession P01011 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 12 Human
  • Omim: 107280 Human
  • SwissProt: P01011 Human
  • Unigene: 534293 Human
  • Unigene: 710488 Human

• Alternative names
  SERPINA3 antibodyA1A antibodyA1AT antibody

  AACT antibodyAACT_HUMAN antibodyAAT antibodyACT antibodyAlpha 1 antichymotrypsin 1 antibodyAlpha 1 antiproteinase antibodyAlpha 1 antitrypsin antibodyAlpha 1 antitrypsin deficiency antibodyAlpha 1 antitrypsin related protein antibodyAlpha 1 protease inhibitor antibodyAlpha-1-antichymotrypsin His-Pro-less antibodyAntichymotrypsin antibodyAntitrypsin antibodyARGS antibodyATR antibodyCell growth inhibiting gene 24/25 protein antibodyCell growth-inhibiting gene 24/25 protein antibodyGIG 24 antibodyGIG 25 antibodyGIG24 antibodyGIG25 antibodyGrowth inhibiting protein 24 antibodyGrowth inhibiting protein 25 antibodyMGC23330 antibodyMGC88254 antibodyMGC9222 antibodyPI 1 antibodyPI antibodyPI1 antibodyPIL antibodyPRO2275 antibodypsiATR antibodySerine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3 antibodySerine (or cysteine) proteinase inhibitor clade A member 3 antibodySerine proteinase inhibitor clade A member 3 antibodySERPIN A3 antibodySerpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibodySerpin peptidase inhibitor clade A member 3 antibodySERPINA3 antibody

  see all

Anti-alpha 1 Antichymotrypsin antibody images

• 

  Sandwich ELISA - alpha 1 Antichymotrypsin antibody (ab54693)
  Standard Curve for alpha 1 Antichymotrypsin (Analyte: alpha 1 Antichymotrypsin protein (Human) (ab80517) ); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal to alpha 1 Antichymotrypsin (ab54693) at 5µg/ml and Detector Antibody Rabbit polyclonal to alpha 1 Antichymotrypsin (ab9374) at 0.5µg/ml.
• 

  IHC-P - alpha 1 Antichymotrypsin antibody (ab54693)
  alpha 1 Antichymotrypsin antibody (ab54693) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human ovary, clear cell carcinoma.
• 

  Western blot - alpha 1 Antichymotrypsin antibody (ab54693)

  Western blot against tagged recombinant protein immunogen using ab54693 alpha 1 Antichymotrypsin antibody at 1ug/ml. Predicted band size of immunogen is 70 kDa.

  This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Protocols

Protocol Booklet