Anti-BMP7 antibody (ab54904)

Overview

• Product nameAnti-BMP7 antibodySee all BMP7 primary antibodies ...
• Description
  Mouse monoclonal to BMP7
• Tested applicationsWB, ICC/IF more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Recombinant full length protein, corresponding to amino acids 1-432 of Human BMP7

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Developmental Biology
  • Organogenesis
  • Nervous system development

  • Developmental Biology
  • Organogenesis
  • Excretory system development
  • Kidney development

  • Stem Cells
  • Signaling Pathways
  • TGF beta
  • Secreted

  • Cancer
  • Cell cycle
  • Cell differentiation

  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • Structures
  • Bone

  • Signal Transduction
  • Growth Factors/Hormones
  • TGF

  • Cell Biology
  • Cell Cycle
  • Cell differentiation

Applications

Target

• FunctionInduces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
• Tissue specificityExpressed in the kidney and bladder. Lower levels seen in the brain.
• Sequence similaritiesBelongs to the TGF-beta family.
• Developmental stageExpressed in the developing eye, brain and ear during embryogenesis.
• Post-translational
  modificationsSeveral N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).
• Cellular localizationSecreted.

Target information above from: UniProt accession P18075 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 655 Human
  • Entrez Gene: 12162 Mouse
  • Entrez Gene: 85272 Rat
  • Omim: 112267 Human
  • SwissProt: P18075 Human
  • SwissProt: P23359 Mouse
  • Unigene: 473163 Human
  • Unigene: 595 Mouse

  • Unigene: 18030 Rat

  see all

• Alternative names
  BMP 7 antibodyBMP-7 antibodyBmp7 antibody

  BMP7_HUMAN antibodyBone morphogenetic protein 7 antibodyBone morphogenic protein 7 antibodyEptotermin alfa antibodyOP 1 antibodyOP-1 antibodyOP1 antibodyOsteogenic protein 1 antibody

  see all

Anti-BMP7 antibody images

• 

  Western blot - BMP7 antibody (ab54904)
  
  
  Predicted band size : 49 kDa
  BMP7 antibody (ab54904) at 1ug/lane + Raw cell lysate at 25ug/lane.
• 

  Immunocytochemistry/ Immunofluorescence - Anti-BMP7 antibody (ab54904)This image was taken from an abreview submitted by Ruma Raha-Chowdhury.
  ICC/IF image of ab54904 staining of BMP7 in rat primary hippocampal neuron culture. The sections were incubated in 0.3% triton X to permeabilise the cells and in 10% serum to block non-specific protein-protein interactions. The sections were incubated with ab54904 (1:1000) overnight at +4°C, followed by a second incubation with Alexa 488 conjugated secondary antibody. BMP7 (green staining) is observed in the pyramidal cells of the hippocampus.

  See Abreview