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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 1 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionGuanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
    • Sequence similaritiesBelongs to the MCF2 family.
      Contains 1 CRAL-TRIO domain.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 SH3 domain.
      Contains 1 spectrin repeat.
    • DomainThe CRAL-TRIO domain is involved in interaction with inositol phospholipids.
      The DH domain is involved in interaction with CCPG1.
    • Cellular localizationCytoplasm. Cell membrane.

      • Target information above from: UniProt accession O15068 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          ARHGEF 14 antibodyDBL''s big sister antibodyDBS antibody
          FLJ12122 antibodyGuanine nucleotide exchange factor DBS antibodyKIAA0362 antibodyMCF 2L antibodyMCF.2 cell line derived transforming sequence like antibodyMCF.2 transforming sequence-like antibodyMCF2 like protein antibodyMCF2 transforming sequence like protein antibodyMCF2-transforming sequence-like protein antibodyMcf2l antibodyMCF2L_HUMAN antibodyOST antibodyOST oncogene antibody
        see all

      Anti-ARHGEF14 antibody images

      • IHC-P - ARHGEF14 antibody (ab57401)
        IHC-P - ARHGEF14 antibody (ab57401)
        ARHGEF14 antibody (ab57401) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human tonsil.
      • Western blot - ARHGEF14 antibody (ab57401)
        Western blot - ARHGEF14 antibody (ab57401)
        Western blot against tagged recombinant protein immunogen using ab57401 ARHGEF14 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

      References for Anti-ARHGEF14 antibody (ab57401)

      ab57401 has not yet been referenced specifically in any publications.

      Publishing research using ab57401 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"