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Overview

  • Product nameFactor IX proteinSee all Factor IX proteins and peptides ...
  • Protein descriptionFull length native Factor IX protein (purified) (Human).
  • Expression hostNative

    • Properties

  • Purification notesHuman Factor IX is prepared from fresh frozen plasma by a combination of conventional procedures and immunoaffinity chromatography. Purity is determined by SDS-PAGE analysis.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, 50% H2O
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab62544 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
    Functional Studies
  • Application notesActivity was measured using a factor IX clotting assay.
    SDS-PAGE: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Christmas DiseaseChristmas factorCoagulant factor IX
        Coagulation factor 9Coagulation factor IXCoagulation factor IX (plasma thromboplastic component)Coagulation factor IXa heavy chainF9FA9_HUMANFactor 9Factor IX DeficiencyFactor9FactorIXFIXGLA domainHaemophilia BHEMBMGC129641MGC129642P19Plasma thromboplastic componentPlasma thromboplastin componentPTCTruncated coagulation factor IX
      see all
  • FunctionFactor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • Tissue specificitySynthesized primarily in the liver and secreted in plasma.
  • Involvement in diseaseDefects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
    Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
    Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • DomainCalcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
  • Post-translational
    modifications    Activated by factor XIa, which excises the activation peptide.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P00740 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Factor IX protein images

    References for Factor IX protein (ab62544)

    ab62544 has not yet been referenced specifically in any publications.

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