Anti-CD11b antibody [2Q902] (ab63317)

Overview

• Product nameAnti-CD11b antibody [2Q902]See all CD11b primary antibodies ...
• Description
  Mouse monoclonal [2Q902] to CD11b
• SpecificityRecognizes CD11b. Reacts with the CR3-receptor of inactivated C3b component of complement (C3bi).
• Tested applicationsIP, Flow Cyt, IHC-P, ICC/IF more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Leukemic cells of CML

• Positive controlcell line HL-60

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityIgG fraction
• Clonality Monoclonal
• Clone number2Q902
• IsotypeIgG2a
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Hematopoietic Stem Cells
  • Murine Lineage Negative

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Neutrophil Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • NK Cell Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • B Lymphocytic Lineage

  • Stem Cells
  • Mesenchymal Stem Cells
  • Negative Markers

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Integrins
  • Alpha

  • Tags & Cell Markers
  • Cell Type Markers
  • Neuroscience Markers
  • Glial

  • Neuroscience
  • Cell Type Marker
  • Glia marker
  • Microglia marker

Applications

Target

• FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
• Tissue specificityPredominantly expressed in monocytes and granulocytes.
• Involvement in diseaseGenetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
• Sequence similaritiesBelongs to the integrin alpha chain family.
  Contains 7 FG-GAP repeats.
  Contains 1 VWFA domain.
• DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
• Cellular localizationMembrane.

Target information above from: UniProt accession P11215 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3684 Human
  • Omim: 120980 Human
  • SwissProt: P11215 Human
  • Unigene: 172631 Human

• Alternative names
  Antigen CD11b p170 antibodyCD11 antigen like family member B antibodyCD11 antigen-like family member B antibody

  CD11b antibodyCD11b antigen antibodyCD11b/CD18 antibodyCD49d antibodyCell surface glycoprotein MAC 1 alpha subunit antibodyCell surface glycoprotein MAC-1 subunit alpha antibodyCell Surface Glycoprotein MAC1 Alpha Subunit antibodyComplement component 3 receptor 3 subunit antibodyComplement Component Receptor 3 Alpha antibodyComplement receptor type 3, alpha subunit antibodyCR 3 alpha chain antibodyCR-3 alpha chain antibodyCR3 Alpha Chain antibodyCR3 antibodyCR3A antibodyF730045J24Rik antibodyIntegrin Alpha M antibodyIntegrin alpha M chain antibodyIntegrin alpha M complement component 3 receptor 3 subunit antibodyIntegrin alpha-M antibodyIntegrin beta 2 alpha subunit antibodyITAM_HUMAN antibodyITGAM antibodyLeukocyte Adhesion Receptor MO1 antibodyLy-40 antibodyMAC 1 antibodyMac-1a antibodyMAC1 antibodyMac1, alpha subunit antibodyMAC1A antibodyMacrophage antigen alpha polypeptide antibodyMGC117044 antibodyMo1, alpha subunit antibodyMO1A antibodyNeutrophil adherence receptor alpha M subunit antibodyNeutrophil Adherence Receptor antibodySLEB6 antibody

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Anti-CD11b antibody [2Q902] images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD11b antibody [2Q902] (ab63317)This image is courtesy of an anonymous Abreview
  ab63317 staining CD11b in Human spleen tissue sections by IHC-P (Formaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 10% serum for 30 minutes at 20°C; antigen retrieval was enzymatic. Samples were incubated with primary antibody (1/50 in antibody diluent) for 30 minutes at 20°C. An undiluted HRP-conjugated goat anti-mouse/rabbit IgG polymer was used as secondary antibody.

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