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Overview

  • Product nameAnti-SHP1 antibody [PTY6]See all SHP1 primary antibodies ...
  • Description
    Mouse monoclonal [PTY6] to SHP1
  • SpecificityThis antibody recognizes the SH2(C) domain of the 67 kDa SHP1 (PTP1C)
  • Tested applicationsICC, IP, WB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC ICC: Use at an assay dependent concentration.
IP IP: Use at an assay dependent concentration.
WB WB: Use at an assay dependent concentration.

Target

  • FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications    Phosphorylated on serine and tyrosine residues.
  • Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

    • Target information above from: UniProt accession P29350 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        70Z-SHP antibodyEC 3.1.3.48 antibodyHCP antibody
        HCPH antibodyHematopoietic cell phosphatase antibodyHematopoietic cell protein tyrosine phosphatase antibodyHematopoietic cell protein-tyrosine phosphatase antibodyHPTP1C antibodyProtein tyrosine phosphatase 1C antibodyProtein tyrosine phosphatase non receptor type 6 antibodyProtein tyrosine phosphatase SHP 1 antibodyProtein tyrosine phosphatase SHP1 antibodyProtein-tyrosine phosphatase 1C antibodyProtein-tyrosine phosphatase SHP-1 antibodyPTN6_HUMAN antibodyPTP-1C antibodyPTP1C antibodyPTPN6 antibodySH PTP 1 antibodySH-PTP1 antibodySHP 1L antibodySHP1 antibodySHP1L antibodyTyrosine-protein phosphatase non-receptor type 6 antibody
      see all

    References for Anti-SHP1 antibody [PTY6] (ab658)

    ab658 has not yet been referenced specifically in any publications.

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