Overview
Product nameWnt10b peptide
Protein descriptionSynthetic peptide derived from within residues 1 - 100 of Human Wnt10b.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab66721 - Wnt10b antibody.
Protein length389 amino acids
Properties
Purity70 - 90% by HPLC
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab66721 and ab155332.
Protein info
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Alternative names
Protein Wnt-10bProtein Wnt-12SHFM6
wingless type MMTV integration site family, member 10BWN10B_HUMANWnt10bwnt12
see all
FunctionLigand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Tissue specificityDetected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
Involvement in diseaseDefects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6) [MIM:225300]. SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder.
Sequence similaritiesBelongs to the Wnt family.
Developmental stageInfant brain has higher levels of WNT10B than adult brain.
Cellular localizationSecreted > extracellular space > extracellular matrix.
References for Wnt10b peptide (ab66720)
ab66720
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
