Anti-Chromogranin A antibody [LK2H10 + PHE5] (ab715)
Overview
- Product nameAnti-Chromogranin A antibody [LK2H10 + PHE5]See all Chromogranin A primary antibodies ...
- DescriptionMouse monoclonal [LK2H10 + PHE5] to Chromogranin A
- SpecificityThis antibody recognizes a protein of 68-75 kDa, identified as chromogranin A (a protein of 439-amino acid which is encoded on chromosome 14).
- Tested applicationsICC/IF, IHC-P, IHC-Fr more details
- Species reactivityReacts with: Human, Monkey
- Immunogen
Human pheochromocytoma
- EpitopeAlthough the epitopes for these two clones are not precisely mapped, experimental data suggest that they are different.
- Positive controlPancreas, adrenal gland, bowel and thyroid
- General notesThis antibody is a mixture of two clones, LK2H10 and PHE5.
Properties
- FormLiquid
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: Proprietary, not sodium azide or thimerosal.
Constituents: PBS, Tissue Culture Supernatant. pH 7.3; Protein carrier. -
Concentration information loading... - PurityProtein G purified
- Clonality Monoclonal
- Clone numberLK2H10 + PHE5
- MyelomaP3-NS1/1-Ag4-1
- IsotypeIgG1
- Light chain typeunknown
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab715 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ICC/IF | ICC/IF: Use at an assay dependent dilution. |
| IHC-P | IHC-P: 1/50 - 1/100. |
| IHC-Fr | IHC-Fr: Use at an assay dependent dilution. |
Target
- FunctionPancreastatin strongly inhibits glucose induced insulin release from the pancreas.
- Sequence similaritiesBelongs to the chromogranin/secretogranin protein family.
- Post-translational
modificationsSulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans. - Cellular localizationSecreted. Neuroendocrine and endocrine secretory granules.
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Database links
- Entrez Gene: 1113 Human
- Omim: 118910 Human
- SwissProt: P10645 Human
- Unigene: 150793 Human
Target information above from: UniProt accession
P10645
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- beta Granin antibodyCGA antibodyCHG A antibody
- CHGA antibodyChromogranin A parathyroid secretory protein 1 antibodyChromogranin A precursor antibodyChromograninA antibodyCMGA_HUMAN antibodyER-37 antibodyPancreastatin antibodyParastatin antibodyParathyroid secretory protein 1 antibodyPituitary secretory protein I antibodySP I antibodySP-I antibodySP1 antibodySPI antibodyVasostatin antibodyVasostatin I antibodyVasostatin II antibody
see all
References for Anti-Chromogranin A antibody [LK2H10 + PHE5] (ab715)
This product has been referenced in:
- Burke AP et al. Carcinoids of the jejunum and ileum: an immunohistochemical and clinicopathologic study of 167 cases. Cancer 79:1086-93 (1997). Read more (PubMed: 9070484) »
- Angelsen A et al. Neuroendocrine differentiation in carcinomas of the prostate: do neuroendocrine serum markers reflect immunohistochemical findings? Prostate 30:1-6 (1997). Read more (PubMed: 9018329) »
