Anti-AADACL1 antibody (ab77486)

Overview

• Product nameAnti-AADACL1 antibodySee all AADACL1 primary antibodies ...
• Description
  Goat polyclonal to AADACL1

  This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

• Species reactivity
  
  Predicted to work with: Mouse, Cow, Human
• Immunogen

  Synthetic peptide: C-RTRNSYIKWLDQN, corresponding to C terminal amino acids 395-407 of human AADACL1 (NP_065843.3)

  Run BLAST with Run BLAST with
• Positive controlHuman brain (Amygdala, Cerebellum, Hippocampus) lysates

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Tumor biomarkers
  • Enzymes
  • Other

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Signaling Pathway
  • Lipid Signaling
  • Other

Applications

Target

• FunctionHydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
• Tissue specificityExpressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
• Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
• Post-translational
  modificationsN-glycosylated.
• Cellular localizationMembrane. Microsome.

Target information above from: UniProt accession Q6PIU2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 57552 Human
  • Entrez Gene: 320024 Mouse
  • Omim: 613234 Human
  • SwissProt: Q6PIU2 Human
  • SwissProt: Q8BLF1 Mouse
  • Unigene: 444099 Human
  • Unigene: 24576 Mouse

• Alternative names
  Arylacetamide deacetylase like 1 antibodyArylacetamide deacetylase-like 1 antibodyNCEH antibody

  Nceh1 antibodyNCEH1_HUMAN antibodyNeutral cholesterol ester hydrolase 1 antibodyNeutral cholesterol ester hydrolase antibody

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