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Anti-Antithrombin III antibody (Biotin) (ab79933)

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Overview

  • Product nameAnti-Antithrombin III antibody (Biotin)See all Antithrombin III primary antibodies ...
  • Description
    Rabbit polyclonal to Antithrombin III (Biotin)
  • ConjugationBiotin
  • Tested applicationsELISA, WB, RIA more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse Antithrombin III purified from mouse plasma

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • PurityProtein G purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab79933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA
WB
RIA
  • Application notesEIA: Use at a concentration of 4 µg/ml.
    RIA: Use at a concentration of 4 µg/ml.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionMost important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
    • Tissue specificityFound in plasma.
    • Involvement in diseaseDefects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
    • Sequence similaritiesBelongs to the serpin family.
    • Post-translational
      modifications      Phosphorylation sites are present in the extracelllular medium.
    • Cellular localizationSecreted > extracellular space.

      • Target information above from: UniProt accession P01008 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          ANT3_HUMAN antibodyAntithrombin antibodyAntithrombin III antibody
          Antithrombin-III antibodyAntithrombinIII antibodyAT 3 antibodyAT III antibodyAT3 antibodyAT3D antibodyATIII antibodyMGC22579 antibodySerine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibodySerine cysteine proteinase inhibitor clade C member 1 antibodySerine proteinase inhibitor clade C member 1 antibodySERPIN C1 antibodySerpin peptidase inhibitor clade C (antithrombin) member 1 antibodySERPINC1 antibodyTHPH7 antibody
        see all

      References for Anti-Antithrombin III antibody (Biotin) (ab79933)

      ab79933 has not yet been referenced specifically in any publications.

      Publishing research using ab79933 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"