Anti-GnRH antibody - C-terminal (ab80002)

Overview

• Product nameAnti-GnRH antibody - C-terminalSee all GnRH primary antibodies ...
• Description
  Rabbit polyclonal to GnRH - C-terminal
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH conjugated synthetic peptide selected from the C terminal region of human GnRH.

• Positive controlHuman brain tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityAmmonium Sulphate Precipitation
• Purification notesThis antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Developmental Biology
  • Reproduction
  • Hormones

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

Applications

Target

• RelevanceGonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
• Cellular localizationSecreted
• Database links
  • Entrez Gene: 2796 Human
  • Entrez Gene: 2796 Human
  • Omim: 152760 Human
  • SwissProt: P01148 Human
  • SwissProt: P01148 Human

• Alternative names
  GNRH1 antibodyGonadotrophin releasing hormone 1 antibodyGRH antibody

  LNRH antibodyLuteinizing releasing hormone antibodyLutenizing hormome releasing hormone antibodyProgonadoliberin 1 antibodyProgonadoliberin I antibody

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Anti-GnRH antibody - C-terminal images

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GnRH antibody - C-terminal (ab80002)
  Formalin-fixed and paraffin-embedded human brain tissue reacted with ab80002 at a 1/10-1/50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.