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Overview

  • Product nameIL10 protein (Human)See all IL10 proteins and peptides ...
  • Protein descriptionRecombinant full length Human IL10 (amino acids 19-178) expressed in modified human 293 cells (Swiss-Prot P22301).
  • Expression hostHEK 293 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
  • Storage instructionsStore at +4°C.
  • Storage bufferPreservative: None
    Constituents: 10% Trehalose, 1% Human serum albumin
  • Concentration information loading...
  • Sequence notesTheoretical Sequence: SPGQGTQSENSCTHFPGNLPNMLRDLRDA FSRVKTFFQMKDQLDNLLLKESLLEDFKGYLG CQALSE MIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRR CHRFLPCENKSKAVE QVKNAFNKLQEKGIYKAMSEFDI FINYIEAYMTMKIRN
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84147 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
  • Application notesSDS-PAGE: Use at an assay dependent dilution.

    Molecular Mass: ab84147 migrates as a band between 10 and 20 kDa in SDS-PAGE. This compares with predicted molecular mass of 18.6 kDa.

    pI: ab84147 separates into a number of isoforms with a pI between 3.0 and 9.0 in 2D PAGE due to post-translational modifications. This compares with the unmodified protein that has a predicted pI of 7.63.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        CSIFCytokine synthesis inhibitory factorGVHDS
        IL 10IL-10IL10IL10_HUMANIL10AInterleukin 10Interleukin-10MGC126450MGC126451T-cell growth inhibitory factorTGIF
      see all
  • FunctionInhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
  • Tissue specificityProduced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
  • Sequence similaritiesBelongs to the IL-10 family.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P22301 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for IL10 protein (Human) (ab84147)

    ab84147 has not yet been referenced specifically in any publications.

    Publishing research using ab84147 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"