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PDGF Receptor alpha protein (Active) (ab84797)

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Overview

  • Product namePDGF Receptor alpha protein (Active)See all PDGF Receptor alpha proteins and peptides ...
  • Protein descriptionRecombinant fragment of Human PDGF Receptor alpha (550-end) (cytoplasmic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal proprietry tag. Swiss Prot P16234.
  • Expression hostInsect cells

    • Properties

  • Purification notesPurity >90% as determined by densitometry.
  • Biological activitySpecific activity: 12nmol/min/mg.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84797 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Functional Studies
  • Application notesKinase assay: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Detects a band of approximately 95 kDa (predicted molecular weight: 95 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Alpha-type platelet-derived growth factor receptorCD140 antigen-like family member ACD140a
        CD140a antigenMGC74795PDGF alpha chainPDGF-R-alphaPDGFR 2PDGFR alphaPDGFR2PDGFRAPDGFRA/BCR fusionPGFRA_HUMANPlatelet derived growth factor receptorPlatelet derived growth factor receptor 2Platelet derived growth factor receptor alphaPlatelet derived growth factor receptor alpha polypeptideRearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion proteinRHEPDGFRA
      see all
  • FunctionReceptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
  • Tissue specificityExpressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
  • Involvement in diseaseNote=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P16234 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    PDGF Receptor alpha protein (Active) images

    • Functional Studies - PDGF Receptor alpha protein (Active) (ab84797)
      Functional Studies - PDGF Receptor alpha protein (Active) (ab84797)
      Activity of ab84797
    • SDS-PAGE - PDGF Receptor alpha protein (Active) (ab84797)
      SDS-PAGE - PDGF Receptor alpha protein (Active) (ab84797)
      SDS Page analysis of ab84797

    References for PDGF Receptor alpha protein (Active) (ab84797)

    ab84797 has not yet been referenced specifically in any publications.

    Publishing research using ab84797 ? Please let us know so that we can cite the reference in this datasheet

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