Overview
Product nameC1s peptideSee all C1s proteins and peptides ...
Protein descriptionSynthetic peptide derived from within residues 1 - 100 of Human C1s.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab66762 - C1s antibody.
Protein length688 amino acids
Properties
Purity70 - 90% by HPLC
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab66762.
Protein info
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Alternative names
Basic proline rich peptide IB 1C1 esteraseC1S
C1S_HUMANComplement C1s subcomponentComplement C1s subcomponent heavy chainComplement C1s subcomponent light chainComplement component 1 s subcomponentComplement component 1 subcomponent sFLJ44757
see all
FunctionC1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Involvement in diseaseDefects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 1 EGF-like domain.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains.
Post-translational
modificationsThe iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
References for C1s peptide (ab88234)
ab88234
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
