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Overview

  • Product nameAnti-Bcl10 antibody [151]See all Bcl10 primary antibodies ...
  • Description
    Mouse monoclonal [151] to Bcl10
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Human Bcl10

  • EpitopeThe epitope recognized by ab93022 resides within amino acids 122-168 of the Human Bcl10 molecule.
  • Positive controlTonsil

Properties

Applications

Our Abpromise guarantee covers the use of ab93022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionPromotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
    • Tissue specificityUbiquitous.
    • Involvement in diseaseNote=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
      Note=Defects in BCL10 are involved in various types of cancer.
    • Sequence similaritiesContains 1 CARD domain.
    • Post-translational
      modifications      Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.
    • Cellular localizationCytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

      • Target information above from: UniProt accession O95999 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          AI132454 antibodyB cell CLL/lymphoma 10 antibodyB cell lymphoma/leukemia10 antibody
          B-cell CLL/lymphoma 10 antibodyB-cell leukemia/lymphoma 10 antibodyB-cell lymphoma/leukemia 10 antibodyBcl 10 antibodyBcl-10 antibodyBcl10 antibodyBCL10_HUMAN antibodyc E10 antibodyc-E10 antibodyC81403 antibodyCARD containing apoptotic signaling protein antibodyCARD containing molecule enhancing NF kappa B antibodyCARD containing molecule enhancing NF kB antibodyCARD containing molecule enhancing NF-kB antibodyCARD containing molecule enhancing NFkB antibodyCARD containing proapoptotic protein antibodyCARD like apoptotic protein antibodyCARD-containing apoptotic signaling protein antibodyCARD-containing molecule enhancing NF-kappa-B antibodyCARD-containing proapoptotic protein antibodyCARD-like apoptotic protein antibodyCARMEN antibodyCaspase recruiting domain containing protein antibodycaspase-recruiting domain-containing protein antibodycCARMEN antibodycE 10 antibodycE10 antibodyCED 3/ICH 1 prodomain homologous E10 like regulator antibodyCED-3/ICH-1 prodomain homologous E10-like regulator antibodyCED3/ICH1 prodomain homologous E10 like regulator antibodyCellular E10 antibodyCellular homolog of vCARMEN antibodyCellular-E10 antibodyCIPER antibodyCLAP antibodyhCLAP antibodyMammalian CARD containing adapter molecule E10 antibodyMammalian CARD-containing adapter molecule E10 antibodymE 10 antibodymE10 antibodyR-RCD1 antibody
        see all

      References for Anti-Bcl10 antibody [151] (ab93022)

      This product has been referenced in:
      • Shen L  et al. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma. Blood 102:1553-4 (2003). IHC-P ; Human . Read more (PubMed: 12900354) »
      • Ye H  et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157:1147-54 (2000). WB, IHC-P ; Human . Read more (PubMed: 11021819) »

      See all 3 Publications for this product

      Publishing research using ab93022 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"