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Overview

  • Product name53BP1 peptideSee all 53BP1 proteins and peptides ...
  • Protein length19 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab87097.

    • Protein info

    • Alternative names
        53 BP153BP1FLJ41424
        MGC138366p202p53 binding protein 1p53 BP1p53-binding protein 1p53BP1TP53 BP1TP53B_HUMANTp53bp1TRP53 BP1Tumor protein 53 binding protein 1Tumor protein p53 binding protein 1Tumor suppressor p53 binding protein 1Tumor suppressor p53-binding protein 1
      see all
  • FunctionMay have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
  • Involvement in diseaseNote=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
  • Sequence similaritiesContains 2 BRCT domains.
  • Post-translational
    modifications    Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
    Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.
  • Cellular localizationNucleus. Chromosome > centromere > kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.

    • Target information above from: UniProt accession Q12888 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for 53BP1 peptide (ab98293)

    ab98293 has not yet been referenced specifically in any publications.

    Publishing research using ab98293 ? Please let us know so that we can cite the reference in this datasheet

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