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Anti-IGF1 Receptor alpha subunit antibody [2C8] (ab987)

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Overview

  • Product nameAnti-IGF1 Receptor alpha subunit antibody [2C8]See all IGF1 Receptor alpha subunit primary antibodies ...
  • Description
    Mouse monoclonal [2C8] to IGF1 Receptor alpha subunit
  • SpecificityThis antibody reacts specifically with the IGF1 receptor alpha subunit.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified human placental IGF-1 receptors.

Properties

Applications

Our Abpromise guarantee covers the use of ab987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesDilute in PBS or medium which is identical to that used in the assay system.
    This antibody has no effect on the binding of IGF-1 or -2 to their receptor.

    • Target

    • RelevanceIGF1 Receptor is a tetramer of 2 alpha and 2 beta chains, linked by disulfide bonds. IGF1 Receptor, like insulin receptor, is synthesized as a single polypeptide which is glycosylated and proteolytically cleaved to give the alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity. It is assumed that, as for the insulin receptor, the tyrosine kinase activity is essential for IGF-1 action. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. It interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. IGF1 Receptor forms a hybrid receptor with INSR, the hybrid being a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R.
    • Cellular localizationMembrane; Single-pass type I membrane protein.
    • Database links
      • Alternative names
          CD221 antibodyCD221 antigen antibodyIGF I receptor antibody
          IGFIR antibodyInsulin like growth factor I receptor antibodyJTK13 antibody
        see all

      References for Anti-IGF1 Receptor alpha subunit antibody [2C8] (ab987)

      This product has been referenced in:
      • Li SL  et al. Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor. Biochem Biophys Res Commun 196:92-8 (1993). Read more (PubMed: 8216340) »

      See 1 Publication for this product

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"