You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Applications

  • Application notesThis peptide can be used with studies using ab84844.

    • Protein info

    • Alternative names
        CD107 antigen-like family member BCD107bLAMP 2
        LAMP 2CLAMP-2LAMP2LAMP2_HUMANLAMPBLGP110Lysosome associated membrane protein 2Lysosome-associated membrane glycoprotein 2Lysosome-associated membrane protein 2MAC3
      see all
  • FunctionImplicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
  • Tissue specificityIsoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
  • Involvement in diseaseDefects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
  • Sequence similaritiesBelongs to the LAMP family.
  • Post-translational
    modifications    O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
  • Cellular localizationCell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.

    • Target information above from: UniProt accession P13473 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for LAMP2 peptide (ab98943)

    ab98943 has not yet been referenced specifically in any publications.

    Publishing research using ab98943 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab98943 Submit a Question for ab98943

    There are currently no Abreviews or Questions for ab98943.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"