Anti-DERL3 antibody (ab99107)

Overview

• Product nameAnti-DERL3 antibodySee all DERL3 primary antibodies ...
• Description
  Rabbit polyclonal to DERL3
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Cow
• Immunogen

  Synthetic peptide corresponding to a region within internal amino acids 71-120 (FFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMT LLGLLGSLFFL) of Human DERL3 (NP_001002862).

  Run BLAST with Run BLAST with
• Positive controlTHP1 cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • ER Proteins

Applications

Target

• FunctionFunctional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
• Tissue specificityUnlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
• Sequence similaritiesBelongs to the derlin family.
• Cellular localizationEndoplasmic reticulum membrane.

Target information above from: UniProt accession Q96Q80 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 614334 Cow
  • Entrez Gene: 91319 Human
  • Entrez Gene: 91319 Human
  • Entrez Gene: 70377 Mouse
  • Omim: 610305 Human
  • SwissProt: Q0P5E4 Cow
  • SwissProt: Q96Q80 Human
  • SwissProt: Q96Q80 Human

  • SwissProt: Q9D8K3 Mouse
  • Unigene: 593679 Human
  • Unigene: 275878 Mouse

  see all

• Alternative names
  C22orf14 antibodyDegradation in endoplasmic reticulum protein 3 antibodyDER 3 antibody

  Der1 like domain family member 3 antibodyDer1 like protein 3 antibodyDer1-like protein 3 antibodyDER3 antibodyDERL 3 antibodyDerl3 antibodyDERL3_HUMAN antibodyDerlin 3 antibodyDerlin 3 protein antibodyDerlin-3 antibodyDerlin3 antibodyDERtrin 3 antibodyDERtrin-3 antibodyDERtrin3 antibodyIZP 6 antibodyIZP6 antibodyLLN 2 antibodyLLN2 antibodyMGC71803 antibody

  see all

Anti-DERL3 antibody images

• 

  Western blot - DERL3 antibody (ab99107)
  Anti-DERL3 antibody (ab99107) at 1 µg/ml + THP1 Cell Lysate at 10 µg
  
  Predicted band size : 27 kDa